March Haemoglobinuria

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Low plasma haptoglobin in march haemoglobinuria.

A student had haemoglobin in the urine after running but not after cycling. The haemoglobinuria was related to the hardness of the surface on which he ran and to his running style. The concentration of haptoglobin in his plasma was less than normal. This was most pronounced after he had been running, when haptoglobin had combined with free haemoglobin, but the concentration was also low when th...

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Paroxysmal Nocturnal Haemoglobinuria

A Clinico-Pathological Conference held in the University of Bristol on the 6th November 1962 chairman: professor t. f. hewer Dr. Crow: This lady was 57 at the time of death and although her early history isi little scanty it seems likely that the disease which ultimately caused her death first presented around the age of 21. We have nothing like complete notes up to 1953, but even so her notes ...

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Haemoglobinuria in the Newborn

Haemoglobinuria occurring at any age is an interesting study, but the dramiiatic character of its onset and its striking symptomatology in the newborn, combined with the additional information which more frequent post-mortem investigation affords, lend special interest to heemoglobinuria in early infancy. The literature on this subject is almost entirely foreign, for, whereas several cases have...

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The complement system plays a central part in both innate and acquired immunity, but the contribution of complement activation to pathobiology is largely ancillary. An exception to the non-dominant role of complement in disease is the haemolytic anaemia of paroxysmal nocturnal haemoglobinuria (PNH). The intravascular haemolysis that is the clinical hallmark of PNH is a consequence of deficiency...

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ژورنال

عنوان ژورنال: BMJ

سال: 1944

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.4355.844